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CECR2 (GST)

Part Number:RD-11-194
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Human recombinant CECR2 bromodomain. CECR2, along with SMARCA1 (SNF2L) forms the ATP-dependent chromatin remodeling complex CERF and plays an essential role in neural tube formation. The CECR2 bromodomain displays binding affinity for mutiple histone H2A and H3 Lys(Ac) residues in singly acetylated histone peptide microarrays (H2A: K15Ac, K36Ac, K75Ac; H3: K9Ac, K14Ac, K18Ac & others), with the H3K9Ac and H3K14Ac interactions confirmed by isothermal titration calorimetry (ITC). A crystal structure for the CECR2 binding domain has been determined.

ACCESSION #: NM_031413

Uniprot Link

INCLUDES AMINO ACIDS: 425-538

TAG(S): N-terminal GST tag

MW: 40.6 kDa

EXPRESSION SYSTEM: E.coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 500 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v)

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.

 
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