C-646
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
C-646 is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM )1. Induces apoptosis in prostate cancer cells2. Enhances fear extinction memory and synaptic plasticity in mice3. Promotes tau deacetylation reducing levels of pathogenic p-tau4. Cell permeable.
Physical Properties: Orange powder
MW=445.4 C24H19N3O6
Analysis: >98% (TLC); NMR (conforms)
Solubilization: May be dissolved in DMSO (10 mg/ml)
Storage: Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 2 months.
Amount: 5 mg
