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Your Price:$303.00
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Part Number:RD-11-260

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Human recombinant BRPF1b bromodomain (shorter BRPF1 isoform, isoform 2). A scaffolding component of the MOZ/MORF histone acetyltransferase (HAT) complex and also an HBO1-BRPF1 HAT complex, native BRPF1b contains, in addition to its acetyllysine-binding bromodomain, two other presumed histone/chromatin binding domains, a PWWP domain and a PHD zinc-finger. The BRPF1 bromodomain binds multiple acetyllysines in histone N-terminal tails, with preference for H2AK5Ac, H4K12Ac and H3K14Ac. BRPF1 forms a complex with MOZ-TIF2 fusion proteins formed due to chromosomal translocations associated with acute myeloid leukemia (AML). Depletion of BRPF1 interferes with the MOZ-TIF2-driven transformation and upregulation of HOX gene expression, suggesting that BRPF1 could be a therapeutic target for AML.

ACCESSION #: NM_004634

Uniprot Link


TAG(S): N-terminal GST tag

MW: 40.5 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v)

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.

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 Substantial Discounts Available on Bulk Quantities

We also offer assay services for BRPF1b (GST).              

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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