customer service


Your Price:$303.00
In Stock.
Part Number:RD-11-171

Choose Options


**Please note that shipping and dry ice charges will be included in your final invoice.**

Human recombinant BRDT, tandem construct comprising bromodomains 1 and 2, expressed as an N-terminal GST fusion protein. BRDT, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD3, BRD4), comprises two bromodomains, protein modules that bind epsilon-N-acetyllysine residues.  Mouse BRDT-1 (BRDT bromodomain 1) can bind simultaneously to two acetyllysine residues and, among the multiply acetylated histone tails tested, had the highest affinity for a histone H4 peptide acetylated at lysines 5 and 8 (H4K5AcK8Ac).  Expression of BRDT is testis-specific and deletion of the mouse BRDT-1 causes abnormal spermatid development and sterility.  Human recombinant BRDT, tandem construct comprising bromodomains 1 and 2, expressed with an N-terminal His-tag. BRDT’s functions in spermiogenesis include roles in broad, programmatic regulation of gene expression, mRNA splicing, chromatin remodeling, meiosis, formation of the chromocenter and post-meiotic genome repackaging.  A three-month treatment of male mice with the BET family bromodomain inhibitor, JQ1, reversibly eliminated fertility, highlighting the potential of BRDT-specific inhibition as an approach for pharmacologic male contraception. 

ACCESSION #: NM_001726

Uniprot Link



MW: 68.4 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 500 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v)

STORAGE: -80°C, aliquot and snap-freeze after first use.

View Product Data Sheet

Substantial Discounts Available on Bulk Quantities

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, PA 19355 1-877-347-2368 or 610-722-0247
[email protected]
Reaction Biology Corp. © 2013 all rights reserved.