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BRD9 (GST)

Part Number:RD-11-187
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Human recombinant BRD9 bromodomain. BRD9 has been identified as a subunit of the BAF-subtype of SWI/SNF nucleosome remodeling complexes. The SWI/SNF complexes are the most highly mutated chromatin regulator in human cancers (19.6% in 44 published sequencing studies), although BRD9 subunit is among the least mutated subunits. However, increased copy numbers of the BRD9 gene occur with high frequency in early stage non-small cell lung cancers and in invasive cervical cancers. The BRD9 bromodomain was found to bind, in vitro, to various microarrayed histone H3, singly lysine-acetylated peptides.

ACCESSION #: NM_023924

Uniprot Link

INCLUDES AMINO ACIDS: 135-248

TAG(S): N-terminal GST-tag

MW: 40.1 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 HEPES/NaOH, pH 7.0, 500 mM NaCl, 1 mM TCEP, 10% glycerol as determined by OD280

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted enzyme is not recommended.

 
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