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BRD4-Tndm (GST)

Your Price:$303.00
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Part Number:RD-11-168

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DESCRIPTION:
Human recombinant BRD4, tandem construct comprising bromodomains 1 and 2, expressed as an N-terminal GST fusion protein. BRD4, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD3, BRDT), comprises two bromodomains, protein modules that bind epsilon-N-acetyllysine residues. BRD4-2 (BRD4 bromodomain 2) is the more C-terminal of the two domains in BRD4.  The ubiquitously expressed BRD4 functions as a transcriptional regulator with roles in cell cycle progression and has recently been shown to be an atypical kinase that can phosphorylate RNA Pol II.  Chromosomal translocations that produce BRD4-NUT fusion proteins are implicated in causation of a rare and aggressive cancer, NUT midline carcinoma.  Selective inhibitors of BRD4/BET family bromodomains are showing promise as possible therapeutic agents for cancer and inflammation. 

ACCESSION #: NM_058243

Uniprot Link

INCLUDES AMINO ACIDS: 44-460

TAG(S): GST

MW: 74.1 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 500 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v)

STORAGE: -80°C, aliquot and snap-freeze after first use.

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