BRD4-2 (His)

Part Number:RD-11-141
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BRD4, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD3, BRDT), comprises two bromodomains, protein modules that bind epsilon-N-acetyllysine residues. BRD4-2 (BRD4 bromodomain 2) is the more C-terminal of the two domains in BRD4.The ubiquitously expressed BRD4 functions as a transcriptional regulator with roles in cell cycle progression and has recently been shown to be an atypical kinase that can phosphorylate RNA Pol II.Chromosomal translocations that produce BRD4-NUT fusion proteins are implicated in causation of a rare and aggressive cancer, NUT midline carcinoma.Selective inhibitors of BRD4/BET family bromodomains are showing promise as possible therapeutic agents for cancer and inflammation.

ACCESSION #: NM_058243

Uniprot Link

INCLUDES AMINO ACIDS: 349-460

TAG(S): N-terminal His-tag

MW: 15.8 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 20 mM Tris, pH 7.5, 150 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v) as determined by OD280

STORAGE: -80°C, aliquot and snap-freeze after first use.

 
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