BRD4-1 (GST)

Part Number:RD-11-157
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BRD4, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD3, BRDT), comprises two bromodomains, protein modules that bind epsilon-N-acetyllysine residues.The ubiquitously expressed BRD4 functions as a transcriptional regulator with roles in cell cycle progression and has recently been shown to be an atypical kinase that can phosphorylate RNA Pol II.Recent structural studies have shown that BRD4-1 (BRD4 bromomdomain 1), like the bromodomain 1 of fellow BET family protein BRDT, can bind simultaneously to two acetyllysine residues with appropriate spacing and sequence context, for example a histone H4 peptide acetylated at lysines 5 and 8 (H4K5AcK8Ac).Chromosomal translocations that produce BRD4-NUT fusion proteins are implicated in causation of a rare and aggressive cancer, NUT midline carcinoma.Selective inhibitors of BRD4/BET family bromodomains are showing promise as possible therapeutic agents for cancer and inflammation.

ACCESSION #: NM_058243

Uniprot Link

INCLUDES AMINO ACIDS: 44-170

TAG(S): GST

MW: 42.1 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 20 mM Tris/HCl, pH 7.5, 150 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v)

STORAGE: -80°C, aliquot and snap-freeze after first use.

 
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