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Your Price:$320.00
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Part Number:RD-11-190

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Human recombinant BRD1 bromodomain. Native BRD1 (BRPF-2) contains, in addition to its acetyllysine-binding bromodomain, two other histone binding domains—a PWWP domain (histone H3 K79me2/3 & K36me3 binding) and a PHD zinc-finger (PHD1, N-terminal tail, unmodified histone H3 binding)—as well as a DNA binding domain (PHD2). Although assumed, like fellow family members BRPF-1 and BRPF-3 to perform a scaffolding function as part of MOZ/MORF histone acetyltransferase (HAT) complexes, BRD1 has been shown to form a complex with another MYST-family HAT, HBO1, plus ING4, and to be required for H3K14 acetylation and erythropoiesis.

ACCESSION #: NM_014577

Uniprot Link


TAG(S): N-terminal GST-tag

MW: 42.4 kDa


SUPPLIED AS: Solution of purified recombinant protein in 50 mM HEPES, pH 7.0, 500 mM NaCl, 1 mM TCEP, 10 % glycerol as determined by OD280

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted enzyme is not recommended.

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Substantial Discounts Available on Bulk Quantities

We also offer assay services for BRD1 (GST).

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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