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BIX-01294

Your Price:$93.50
In Stock.
Part Number:EI-HMT-003

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BIX-01294 3HCl  

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride

 

BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 µM) as well as GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro.  It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming.  BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.  It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells.


Physical Properties:  Off-white crystalline powder

MW=600.0       C28H38N6O2  · 3HCl

Analysis:  >98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in water (50 mg/ml); or DMSO (50 mg/ml)

Storage:  Store desiccated as supplied at ambient for up to 2 years. Store solutions at            -20°C for up to 3 months.  

Amount: 5mg                
















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