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Your Price:$98.00
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Part Number:EI-HMT-003

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BIX-01294 3HCl  

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride


BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 µM) as well as GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro.  It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming.  BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.  It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells.

Physical Properties:  Off-white crystalline powder

MW=600.0       C28H38N6O2  · 3HCl

Analysis:  >98% (HPLC); NMR (Conforms)

Solubilization: May be dissolved in water (50 mg/ml); or DMSO (50 mg/ml)

Storage:  Store desiccated as supplied at ambient for up to 2 years. Store solutions at            -20°C for up to 3 months.  

Amount: 5mg                

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

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