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Arecoline HBr

Your Price:$49.50
In Stock.
Part Number:EI-ACAT-001

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1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide


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Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 ?M). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM). May be effective in dementia.

Physical Properties: White crystalline powder

MW=236.1          C8H13NO2  • HBr  

Analysis:  >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in water (50 mg/ml)

Storage:  Store desiccated as supplied at ambient temperature for up to 2 years. Do not store solutions for longer than one day

Amount: 250 mg 











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