customer service

Arecoline HBr

Your Price:$49.50
In Stock.
Part Number:EI-ACAT-001

**Please note that shipping and dry ice charges will be included in your final invoice.**

1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide

Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 ?M). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM). May be effective in dementia.

Physical Properties: White crystalline powder

MW=236.1          C8H13NO2  • HBr  

Analysis:  >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in water (50 mg/ml)

Storage:  Store desiccated as supplied at ambient temperature for up to 2 years. Do not store solutions for longer than one day

Amount: 250 mg 

With the largest functional kinase activity assay panel in the industry, RBC provides kinase, epigenetic, and other profiling services to over 590 companies worldwide. RBC specializes in custom assay conditions, high quality reproducible data, and outstanding service.

Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, PA 19355 1-877-347-2368 or 610-722-0247
[email protected]
Reaction Biology Corp. © 2013 all rights reserved.