Apicidin



Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]

Apicidin is a cyclopeptide inhibitor of histone deacetylases (HDACs). Inhibits HeLa cell proliferation (IC₅₀=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1a protein levels and transcriptional activity in human and mouse tumor cell lines.Cell permeable.

Physical Properties: white powder

MW=623.8 C₃₄H₄₉N₅O₆

Analysis: =98% (HPLC); NMR (Conforms)

Solubilization: Soluble in DMSO (10 mg/ml); or ethanol (1 mg/ml)

Storage: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.