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Apicidin

Your Price:$71.50
In Stock.
Part Number:EI-HDC-006

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Apicidin



Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]

Apicidin is a cyclopeptide inhibitor of histone deacetylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1).  Decreases HIF1a protein levels and transcriptional activity in human and mouse tumor cell lines.  Cell permeable.


Physical Properties:  white powder

MW=623.8          C34H49N5O6

Analysis:  =98% (HPLC); NMR (Conforms)

Solubilization: Soluble in DMSO (10 mg/ml); or ethanol (1 mg/ml)

Storage:  Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.


Amount: 1mg










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