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5-Fluoro-2'-deoxycytidine

Part Number:EI-DNA-004
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2’-Deoxy-5-fluorocytidine



5-Fluoro-2’-deoxycytidine; FCDR; FdCyd; NSC-48006; Ro 5-1090


2'-Deoxy-5-Fluorocytidine DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors. Like 5’-Azacytidineand decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.

Physical Properties: White solid; MP = 196oC

MW=245.2 C9H12FN3O4

Analysis: >98% (TLC); NMR (Conforms)

Solubilization: May be dissolved in DMSO (20 mg/ml)

Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at-20°C for up to 1 month.


Amount: 50mg